Next to Lublin, Kazimierz Dolny was the second most influential centre of the Lublin Renaissance. This new architectural style was first introduced during the rebuilding of a Gothic parish church in Kazimierz which was destroyed by fire. The new temple was designed by Jakub Balin, a Lublin architect of Italian origin, and erected in the years 1610–1613.

The church has one nave, a lower chancel ending in an apse and two characteristic gables showing influences of Italian and Netherlandish architecture. The barrel vaulting of the nave and the chancel is decorated with ornate stuccos. In the XVII century three chapels were added to the church: of the Borkowski family, of the Górski family, and the Rosary Chapel. Inside, next to the choir stands a historical XVII century organ – the oldest, complete musical instrument of this kind in Poland. Elements of the interior worthy of mention include Rococo confessionals, a stone font made in Santi Gucci’s workshop, and XIX century altar paintings depicting St. Bartholomew and Casimir Jagiellon.